Minggu, 28 November 2010

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Bioequivalence and Statistics in Clinical Pharmacology (Chapman & Hall/CRC Biostatistics Series) 1st edition

  • Published on: 1600
  • Binding: Hardcover

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Jumat, 26 November 2010

[T528.Ebook] Get Free Ebook Spain (Small Panorama Series), by Emma Howard

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Spain (Small Panorama Series), by Emma Howard

Spain Emma Howard Small Panorama Series

  • Sales Rank: #1272778 in Books
  • Published on: 2009-01-28
  • Original language: English
  • Number of items: 1
  • Dimensions: 1.01" h x 10.81" w x 7.79" l, 2.68 pounds
  • Binding: Hardcover
  • 256 pages

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0 of 0 people found the following review helpful.
Five Stars
By Alicia
Nice photos!

0 of 0 people found the following review helpful.
but like yours better
By Judy Parr
Splendid photos. Looked for such a book in Spain, but like yours better.

1 of 1 people found the following review helpful.
Surprisingly beautiful photos
By EcoDesigner
I am often disappointed with photo books and wonder how the photographers/editors can make such beautiful places appear common, but this is not one of those books. I was very impressed with the quality of the photos and the variety of subjects. Very nice book!

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Minggu, 21 November 2010

[J610.Ebook] PDF Download Fitness over 50: Weekly Workout Plan! (Success Over 50 Book 2), by Christopher Quinn

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Fitness over 50: Weekly Workout Plan! (Success Over 50 Book 2), by Christopher Quinn

Are you over the age of 50 and desire to shake things up and become VERY FIT? In this short report we discuss the exact workout that will get you muscular, lean and in the best shape of your life! Even if you are over the age of 50… like me!

Let me guide you as to how I work-out. What I eat. And how I stay lean. If you are over the age of 50 there is no better time to get VERY FIT!! And have the body you truly desire despite your age!!

Fitness over 50: Weekly Workout Plan! by Christopher Quinn

  • Sales Rank: #134816 in eBooks
  • Published on: 2015-07-05
  • Released on: 2015-07-05
  • Format: Kindle eBook

Most helpful customer reviews

10 of 11 people found the following review helpful.
It is pretty solid for what it is
By Rich W
Okay, it is a short, quick overview of what is really a minimalist approach to fitness for someone over 50 years of age. I gave it one star for its price. At $3.00, I would have rated it four stars; over $5.00 I would have given it 3. It is pretty solid for what it is, no fluff. It is not an exhaustively footnoted, highly-researched scientific report, but the anecdotal experience of the author, which I believe is authentic enough to be believable. I believe it, or a similar workout based on the same broad principles, will work for people over 40 who don't want to spend too much time at the gym and aren't pursuing sports like mma, seniors volleyball, competitive swimming, etc., but rather are seeking to stay healthy, with good muscle mass, not too much bodyfat, a good metabolism, and a healthy heart. And, who want to achieve that without too intensive of workouts--no marathons, no Crossfit or Strongman, no high-risk activities. For those goals, this workout should be effective. It is also intended to make one look "good" in a conventional way, with relatively large chest, shoulder, arm, and upper back muscles. In sum, the weight workout is intended make one relatively healthy and healthy-looking.

The aerobic work is pretty simple and also low-intensity, which should make it accessible to most people, or at least part of it--it calls for devoting an hour a day, four or five days a week to it. I don't recall him mentioning it, but certainly 20 or 30 minutes would be pretty good if an hour is too long for a beginner. The dietary guidelines are pretty good as well, and also should be workable for anyone who seriously wants to keep themselves at a healthy weight.

I should add that the author mentions some injuries, especially back surgery and knee problems from running a lot when younger. This is probably why there is no low back/hip/leg exercising. This workout is not written in stone, so one could add some such work into the workout if so desired. There is no flexibility or mobility work either, but again there is no reason why this can't also be done. In fact, this is only a skeleton workout--one could do it and also play tennis, ping-pong, surf--anything basically--and still follow most of this program.

I have some minor criticisms of the program. First, he exclusively uses weight machines, mainly for safety he says. I think it is unnecessary, but okay, he has his reasons. Second, he focuses on the mirror muscles. Third, he doesn't program in any flexibility work. Fourth, carbs are not the enemy--they have their place in our diets, it is only their abuse that creates problems, but he insists on blaming obesity primarily on them, rather than our hectic, sedentary lifestyles. And there are some others, even more minor than these.

I think mainly he is so focused on simplicity that it limits his program in some ways. But for some people, that is what they want. For those with injuries (common among the 50+ set who are his intended audience) that limit their back and leg work, the program might be actually very well-suited. For others, they can work in additional exercises that he leaves out. Basically, it is a simple push/pull/ab weight program, a low-intensity aerobic program, with a low-carb, IF-style diet. It is definitely practical and doable for many of us old folks.

3 of 4 people found the following review helpful.
Mother Becoming Fit Again!
By Amazon Customer
After starting Strength at 50!: Get Strong and Fit Today! (I highly recommend), this book gives similar very good information. Even though I'm a 47 year old woman, and mother of 2 teenagers, I have felt a need to get back in shape again (don't we all!). I've been reading about how strength training is a very good thing for you whole body whether you're a man or a woman. I've started using the information in both these books when I'm lifting weights in the gym, and I'm starting to see alot more toned muscle in every part of my body. I like how this author also gives details about what he eats and when. Although I may take in less calories, it's a good framework. Worth buying!

0 of 0 people found the following review helpful.
Quinn makes the point quite clearly, think how you ...
By Amazon Customer
Quinn makes the point quite clearly, think how you may appear to yourself and your significant partner when you are naked.
Training program a bit difficult to follow.

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Rabu, 17 November 2010

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Molecular Biology of the Cell, Fourth Edition, by Bruce Alberts, Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts, Peter Walter

Molecular Biology of the Cell is the classic in-dept text reference in cell biology. By extracting the fundamental concepts from this enormous and ever-growing field, the authors tell the story of cell biology, and create a coherent framework through which non-expert readers may approach the subject. Written in clear and concise language, and beautifully illustrated, the book is enjoyable to read, and it provides a clear sense of the excitement of modern biology. Molecular Biology of the Cell sets forth the current understanding of cell biology (completely updated as of Autumn 2001), and it explores the intriguing implications and possibilities of the great deal that remains unknown. The hallmark features of previous editions continue in the Fourth Edition. The book is designed with a clean and open, single-column layout. The art program maintains a completely consistent format and style, and includes over 1,600 photographs, electron micrographs, and original drawings by the authors. Clear and concise concept headings introduce each section. Every chapter contains extensive references. Most important, every chapter has been subjected to a rigorous, collaborative revision process where, in addition to incorporating comments from expert reviewers, each co-author reads and reviews the other authors' prose. The result is a truly integrated work with a single authorial voice. Features : - Places the latest hot topics sensibly in context - including genomics, protein structure, array technology, stem cells and genetics diseases. - Incorporates and emphasises new genomic data. - All of molecular biology is brought together into one section (chapters 4-7) covering classically defined molecular biology and molecular genetics. - Two chapters deal exclusively with methods and contain information on the latest tools and techniques. - New chapters on "Pathogens, Infection, and Innate Immunity". - Cell Biology Interactive CD-ROM is packaged with every copy of the book. - Contains over 1,600 illustrations, electron micrographs and photographs, of which over 1,000 are originally conceived by the authors.

  • Sales Rank: #82148 in Books
  • Published on: 2002-03
  • Ingredients: Example Ingredients
  • Original language: English
  • Number of items: 1
  • Dimensions: 1.98" h x 8.70" w x 10.86" l, 1.10 pounds
  • Binding: Hardcover
  • 1616 pages
Features
  • Cell Biology Interactive CD included

Review

"In an era when we are drowning in information, the job of a textbook such as Molecular Biology of the Cell is to help teach its readers how to swim. This it does admirably, and the punctilious attention to detail and effort devoted by the authors to covering this huge field in a lucid and easy-to-read style shines though on every page... the fourth edition of Molecular Biology of the Cell is an outstanding textbook... The clear and concise style and copious informative diagrams and illustrations set an impressive standard, and the comprehensive coverage of the field that has been achieved is quite remarkable." - Nature

 

"The book is extremely well written... The hundreds of schematic/explanatory diagrams and light and electron micrographs and the way they are integrated into the text are superb... This 4th edition will be warmly welcomed by college and university teachers, researchers and students alike. It maintains and improves upon the quality and excellence of previous editions." - Doody's Reviews

 

"The 4th edition of the Molecular Biology of the Cell does an excellent job of reporting our progress, and the next generation of purchasers should not regret the presence of this text on their bookshelves." - Cell

 

"... what is to be said about the fourth edition of Molecular Biology of the Cell? The most casual glance confirms that standards have not slipped: short subsections with informative headings, highlighted key words, italicised chapter summaries and diagrams of great clarity... it should be remembered that Molecular Biology of the Cell set the precedent of providing a substantial problems book, and Tim Hunt and John Wilson have contributed a revised version of this supplement for the fourth edition... the sheer scale of coverage by the fourth edition of Molecular Biology of the Cell means it will be the first thing most of us will reach for in pursuit of the facts of life." - Journal of Cell Science

 

"... a new kind of encyclopedia is taking shape, and for a new kind of audience. They don't just make an up-to-date alphabetical tour of some circumscribed area of human knowledge; They also try to put all that knowledge in context. The best I've yet encountered is a Molecular Biology of the Cell... It's essentially a single 1,500-plus-page essay on the microcosm that lurks invisibly at the very roots of the tree of life... the authors digest their material so brilliantly one can--with patience and a decent high-school science education--actually read the damn thing... [the] authors have with each edition improved every aspect of the book, polishing its plain, transparent prose, clarifying descriptions, enhancing illustrations... It's an easy book to like, too..." - Seattle Weekly

 

"Molecular Biology of the Cell, a hefty tome written for a wide range of students, as well as scientists wishing to follow the rapid progress in their specialized fields, delivers on its promise to give readers the most comprehensive text possible. At first glance, it doesn't seem possible that the authors had to decide what details to leave out. It looks as if they'd covered it all. From a basic discussion of cells, genomes, and cell chemistry to DNA, cellular organization, function and cell immunity, the authors have incorporated facts, specific examples, and essential concepts in a way that makes this new edition a landmark work in the field of molecular cell biology. As genomics expands more rapidly than anyone thought possible, and complete sequencing of genomes from bacteria to humans has revolutionized our understanding of living things, new information is critical. Included in this amazing text are discussions of new discoveries in biotechnology, cellular mechanisms, infection and immunity. Without sacrificing content, the authors have put together a remarkable book that can be used for courses in cell biology or molecular biology (chapters 1 through 8). Outstanding drawings, photographs, and diagrams fill the chapters to enhance the excellent writing. Every instructor will want to keep a reference copy on his or her shelf, whether they use the book for their classes or not. As a textbook, there's not one better. Highly recommended for academic libraries, as well as undergraduate, and graduate courses." - Life Science Book Review

 

Praise for the previous editions:

"The epitome of what a current upper level textbook in cell biology should be."

Quarterly Review of Cell Biology

"Accessible and relatively easy to read... timely and accurate... profusely and beautifully illustrated."

American Society for Microbiology News

"A reliable, accurate and up-to-date textbook for which students and researchers must be grateful."

Trends in Biochemical Sciences

"A big, beautiful (now in color), up-to-date survey of cell biology."

Sci Tech Book News

"The authors and their publisher have once again led the way and set the standard against which other scientific textbooks will be measured."

Biochemical Education

Most helpful customer reviews

145 of 150 people found the following review helpful.
The standard in the field
By Gavin Scott
This review is based (mostly, see update at the end) on the Kindle edition of the book, which is a "Print Replica" edition which exactly matches the printed textbook (it's essentially like a PDF of the entire book). For textbooks, even the most valuable (like this one) that I love and plan to keep for a long time, I now much prefer electronic versions for many reasons, not the least of which is that it's easier to hold up and read a tablet than a seven pound tome. You can also zoom in on text and figures as needed, and the illustrations are almost all in "vector" form meaning they stay sharp and detailed as you zoom in. You can also search the complete text of the book, do electronic underlining, set bookmarks, etc.

Yes, the Kindle textbooks have DRM that restricts what you can do with it, but I find the Kindle restrictions less onerous than many, and in most cases they give you an option to "rent" textbooks for the duration of a class which might be as economic as buying a physical copy and then reselling it when you're done with it. But if you want complete freedom to resell what you buy, or maybe you just like the feeling of holding a real book in your hands, then the printed copy would probably be what you want. Note that I believe the physical version comes with a disc containing the movies and supplemental materials for the book (turns out it doesn't, see update below), but you can also find all of this free on the Garland Science web site if you buy an e-book version.

So with that out of the way let's talk about the book! There are basically two groups of people who are likely reading this. Either you've had this book assigned as the textbook for a class or you haven't. If this has been assigned as a textbook, first make sure you're looking at the correct edition. This sixth edition is very different from the fifth (the authors point out that five million scientific papers were written since the previous edition) and you might *not* get away with buying a cheaper used previous edition. If your class is going into enough depth that it needs this book over something like Essential Cell Biology, 4th Edition then chances are you really do need the correct edition. Also the sixth edition is brand new as of this writing, so make sure you're not being asked to get the previous (fifth) edition!

This is one of my favorite textbooks of all time. A really good textbook is designed to prepare students to be practitioners in a field, not just to try to keep bored students awake and hold their hands through a class they really wish they didn't have to take. This is a great textbook and it's THE book to get if you want to learn as much about cell biology as is possible from one volume. It's also now entirely fresh and up to date (as of 2014), something absolutely critical in a field like Biology which advances daily. Everything in here is fascinating. If you think this stuff is boring then I feel sorry for you :) Life is cells, and this is "everything we know about how cells work" so it's directly applicable to an understanding of every (known) form of life, from bacteria to you and me. Even if your class doesn't go down into the depths and fine details, this is a great book to have for later self-study if this stuff interests you. This can be a textbook you keep for years and refer to frequently.

This is also a surprisingly accessible work for those interested in learning about modern Biology on their own. If you're someone who is scientifically minded and wants to understand how life works, then most of what's in here is easily comprehensible and highly enjoyable. Unlike many fields, there aren't years of prerequisites needed to start the study of cutting-edge Biology. If this were Physics, you would need to have had ten years of math and boring low-level physics before you could ever hope to begin to understand things like quantum mechanics or the general theory of relativity. But there's no math requirement for understanding Biology (though it's starting to become more quantitative and newer fields like Physical Biology are growing rapidly). A little knowledge of concepts from Chemistry is helpful, but again very little of the discussion in this book is quantitative so there's generally nothing to calculate, no equations to solve, etc. Cell Biology is much closer to something like computer programming in terms of the mental aptitude needed to understand it. To get started I recommend reading chapter 1 thoroughly, then read chapter 2 but if your eyes start to glaze over then just skip the rest of chapter 2 for now (the chemistry, while obviously fundamental and critically important is not necessary to understand deeply in order to understand the rest of the book, just as you don't really need to understand voltages and transistors in order to learn to program a computer), and then read Chapter 3 thoroughly which is all about how proteins perform most of the work in the cell including acting as microprocessors, motors, pumps, etc. By that point you'll likely be hooked and you can go back and appreciate the rest of chapter 2 when you're ready for it.

So how does this Sixth edition compare too the Fifth? Well, first of all it has been seven years since the previous edition, which is nearly forever in the world of Biology, so just on that basis alone the new edition is going to be a big advance. In general the fundamentals are the same, but the fine details of understanding have advanced a great deal.

An ongoing problem for the authors is the incredible volume of knowledge that exists and the near infinite and subtle complexity of even the simplest cells. This means the book could easily be three times its current size, a pressure which the authors must find a way to resist if the book is to remain portable and affordable. In the fifth edition, the book exploded past its covers and the standard edition was forced to relegate the last five chapters to PDF supplements (a huge Reference Edition with over 1600 pages was available with all chapters printed, and the e-book versions include all chapters). This was not a popular decision as it meant that even after buying and lugging around a big expensive tome, you still didn't even have all the content printed.

The sixth edition now includes the entire content of the book, and there's no need for a "Reference" edition. This means however that even though the printed book has gotten slightly longer, they have had to shorten the effective size by about 250 pages! This has resulted in a lot of editing and a reduction in the number of figures. In some cases this means more effective and concise content, but in other places interesting material and in-depth discussion has been eliminated. Taking as an example chapter 4, Control of Gene Expression, the current edition has 79 figures where the previous edition had 115. Also the chapter on Sexual Reproduction has been eliminated entirely (you can download the fifth edition version of this chapter as a PDF, see the update below) though some of its material has been integrated into other parts of the book.

I cannot help but wonder if the authors have really made the right decision here. Choosing to reduce the (effective) size of the book by around 15% at a time when knowledge in the field is growing so rapidly seems rather limiting. I would personally have rather seen them embrace the idea that many of their readers will be using e-books where the length has no physical effect, or even consider breaking the book into two volumes as is often done in fields like the study of medicine. But in the end this is still intended to be a textbook, and many students will likely appreciate anything that reduces the number of pages they have to read :)

A lot of work has been done to clean up the design, and they have re-created many illustrations in a more consistent style. This edition uses a pleasant blue theme in comparison to the reddish-pink of the fifth edition. It has a cleaner look overall, and I think the changes in title/heading color are a definite improvement for on-screen reading. There are a few places where figures include small areas of white-on-lime-green text that I have to zoom in on to read, but generally the changes are improvements.

The content in general has been brought up to date with many sections extensively updated or re-written. Interestingly, as a sign that classic quantitative methods from Physics are starting to creep further into Biology, there's an extended section in chapter 8, Mathematical Analysis of Cell Functions, which gives some mathematical (ZOMG! some math in a Biology book!) treatment to things like gene product equilibrium and gene regulation and serves as a good introduction to the field of Physical Biology, which is another interesting way of approaching the study of life (if you find this interesting then I can also recommend Physical Biology of the Cell which I bought and have been enjoying).

Anyhow, MBoC gets all the stars as being one of those magical books that takes you deep into a whole new and fascinating world, one where you'll learn how each individual cell in your body has much more in common with a modern supercomputer than it does with that soggy old frog you dissected in high-school. The practice of modern cell biology is nothing less than hacking into alien computer systems (not designed by the mind of man) looking for technology we can appropriate or adapt to cure disease, reduce world hunger, produce clean cheap energy, and otherwise improve our lives.

An exciting book for exciting times.

G.

Update: I've now purchased a copy of the physical book as well, just because I like it so much. It's a six pound, 13 ounce tome that's two inches thick. It's hardbound, and has the same feel and quality as the Reference edition version of the fifth edition. Paper quality (thickness, brightness) are again similar to the fifth edition. It's definitely not as lap-crushing as the old Reference edition (that extra pound or so makes a big difference).

The physical book does NOT come with CD media for the supplemental movies and stuff, so you need to go to the Garland Science site to find them (under the Student tab you can search for the movie numbers from the book without needing to create an account, or you can create an account and add the book to it to make accessing things a little easier). The GS site still seems to be rolling out information on the new edition so at some point they may have a page/site dedicated to the book as they have for some other recent textbooks. They have also now added a downloadable PDF of "MBOC, Fifth Edition - Chapter 21: Sexual Reproduction: Meiosis, Germ Cells, and Fertilization" in the sixth edition downloads area. This chapter got eliminated from the sixth edition (the meiosis section in the Cell Cycle chapter was extended a bit to compensate) so this is a useful reference to have.

Update 2: I just picked up the new version of Molecular Biology of the Cell 6E - The Problems Book and it's got many VERY nice improvements over its previous version. It should really be considered "part two" of the textbook. There's a huge amount of additional knowledge in here and it's great to just read, not just as a workbook. Go check it out.

70 of 72 people found the following review helpful.
Updates on the Text and Table of Contents
By Clandestine Library For Further Reading
This edition of the textbook contains numerous updates as expected. However, there is an interesting new additional feature called "What We Don't Know" questions near the summary of every chapter. These questions provide a better glimpse of issues that are either unclear, unknown, in progress, or still being debated among researchers. These questions can be of some use to researchers who are looking for areas that may yield fruitful pioneering opportunities or these questions can be of use to graduate students for their dissertations. Sometimes one is overwhelmed with choosing topics or questions for a dissertation (its an important decision since specialization is required in graduate school) or a grant or a research paper and these questions can provide some brainstorming material. Other novel features or updates in the 6th edition include: explaining newly discovered functions for RNA molecules; a new section in Ch. 8 emphasizing the need for mathematics to unravel the massive complexities of cellular functions (e.g. the use of differential equations to shed light on the incredible amounts of chemical dynamics in cellular processes - similar to how engineers have been using these keep track of system dynamics); focusing on cell signaling with emphasis on key principles in the circuitry of signaling systems; new sections on timing, growth control, and morphogenesis of multicellular organisms; updates on stem cell biology and technologies, etc. One sample on the current flood of data on biological systems, they wrote:

"Empowered by knowledge of complete genome sequences, we can list the genes, proteins, and RNA molecules in a cell, and we have methods that allow us to begin to depict the complex web of interactions between them. But how are we to turn all this information into an understanding of how cells work? Even for a single cell type belonging to a single species of organism, the current deluge of data seems overwhelming. The sort of informal reasoning on which biologists usually rely seems totally inadequate in the face of such complexity. In fact, the difficulty is more than just a matter of information overload. Biological systems are, for example, full of feedback loops, and the behavior of even the simplest of systems with feedback is remarkably difficult to predict by intuition alone; small changes in parameters can cause radical changes in outcome. To go from a circuit diagram to a prediction of the behavior of the system, we need detailed quantitative information, and to draw deductions from that information we need mathematics and computers. Such tools for quantitative reasoning are essential, but not all-powerful. You might think that, knowing how each protein influences each other protein, and how the expression of each gene is regulated by the products of others, we should soon be able to calculate how the cell as a whole will behave, just as an astronomer can calculate the orbits of the planets, or a chemical engineer can calculate the flows through a chemical plant. But any attempt to perform this feat for anything close to an entire living cell rapidly reveals the limits of our present knowledge. The information we have, plentiful as it is, is full of gaps and uncertainties. Moreover, it is largely qualitative not quantitative. Most often, cell biologists studying the cell's control systems sum up the knowledge in simple schematic diagrams - this book is full of them - rather than in numbers, graphs, and differential equations. To progress from qualitative descriptions and intuitive reasoning to quantitative descriptions and mathematical deduction is one of the biggest challenges for contemporary cell biology. So far, the challenge has been met only for a few very simple fragments of the machinery of living cells - subsystems involving a handful of different proteins, or two or three cross-regulatory genes, where theory and experiment go closely hand in hand. We discuss some of these examples later in the book and devote the entire final section of Chapter 8 to the role of quantitation in cell biology. Knowledge and understanding bring the power to intervene - with humans, to avoid or prevent disease; with plants, to create better crops; with bacteria, to turn them to our own uses. All these biological enterprises are linked, because the genetic information of all living organisms is written in the same language." (38)

Some of the best features in the book are the discussions relating to the intersection of design and nature (e.g. fields such as Medicine and Biotechnology). They implicitly show that molecular biology is leaning a bit more towards studying cells as Systems Engineering matters. A good intro to thinking in terms of systems is Systems Engineering and Analysis (5th Edition) (Prentice Hall International Series in Industrial & Systems Engineering) and also Design and Analysis of Biomolecular Circuits: Engineering Approaches to Systems and Synthetic Biology. Indeed, in order to have a comprehensive look at cells, it is essential to not only see what occurs in nature, but also to to see how one can reverse engineer, synthesize, control and redirect nature's course for higher benefits.

The general Table of Contents for the 6th edition is at the very bottom of the review, but I wanted to point out some of the differences compared to the 5th edition early on:

5th edition, there were 25 chapters total, but the last 4 chapters were on a DVD, not the book
6th edition, there are 24 chapters and everything is in one book, but one chapter was left out - can be downloaded from the Garland Science website

5th edition, Ch.2 title was "Cell Chemistry and Biosynthesis"
6th edition, Ch.2 title was replaced with "Cell Chemistry and Bioenergetics"

5th edition, Ch.8 title was "Manipulating Proteins, DNA, and RNA"
6th edition, Ch.8 title was replaced with "Analyzing Cells, Molecules, and Systems"

5th edition, Ch.13 title was "Intracellular Vesicular Traffic"
6th edition, Ch.13 title was replaced with "Intracellular Membrane Traffic"

5th edition, Ch.15 title was "Mechanisms of Cell Communication"
6th edition, Ch.15 title was replaced with "Cell Signalling"

5th edition, Ch.18 title was "Apoptosis"
6th edition, Ch.18 title was replaced with "Cell Death"

5th edition, Ch.19 title was "Cell Junctions, Cell Adhesion, and the Extracellular Matrix"
6th edition, Ch.19 title was replaced with "Cell Junctions and the Extracellular Matrix"

5th edition, Ch.21-25 were: 21. Sexual Reproduction: Meiosis, Germ Cells, and Fertilization, 22. Development of Multicellular Organisms, 23. Specialized Tissues, Stem Cells,and Tissue Renewal, 24. Pathogens, Infection, and Innate Immunity, 25. The Adaptive Immune System
6th edition, Ch.21-24 are : 21. Development of Multicellular Organisms, 22. Stem Cells and Tissue Renewal, 23. Pathogens and Infection, 24. The Innate and Adaptive Immune Systems...NOTE: Chapter 21: Sexual Reproduction: Meiosis, Germ Cells, and Fertilization from the 5th edition can be downloaded from the Garland Science website for the 6th edition for free since it was left out of the 6th edition.

Other free downloads available form the Garland Science book website include : Ch. 20 Cancer (the whole chapter) and the detailed Table of Contents

Cells are not simple things at all, rather they are ridiculously sophisticated nanomachines with self-coding and transcribing capabilities, automated control systems, self-reproductive capabilities, informational and chemical programming, they have multiple energy-source harnessing abilities, etc. Cells are nano-chemical plants that perpetually sustain living organisms 24 hours a day, 7 days a week, 365 days a year nonstop - until they die. It is no wonder that some see cells as artifacts of nanotechnology. What makes it even more mind boggling is that trillions of cells (37 trillion based on an updated estimate as of 2013) make up our own bodies and we have have 200 different cell types with numerous specializations that allow us to fight off diseases, repair our cellular machinery without disrupting the processes of living, execute multiple simultaneous development programs, repair damaged DNA from mutations, reproduce, preform emergency protocols, recover and replenish homeostasis, process and convert food into chemical energy and reserves, give ourselves momentary boosts of energy at will, etc. With all of this, there is bound to be lots of new information and insights to come in the future editions of this textbook. The growth of research into sophisticated regulatory gene networks, Genomics, the growth of Proteomics and Epigenetics, approaches in Synthetic Biology, Genetic Engineering, Biotechnology, Medicine, etc ensure this.

Two recent examples of advances that have provoked reconsideration of the power of cells and their machinery. One is the discovery that 1 gram of DNA can store 700 terabytes of data (later researchers have discovered even more capacity, 2.2 petabytes in 1 gram of DNA). It has implications for biotechnology because the whole internet can be stored in this tiny amount! Perhaps later we will be using DNA instead of flash drives or external hard drives for storage.

Another example is that it has been known that the human genome was made up of 3 billion bases, but some believed that the majority of the genome was non-functional due to protein oriented biases. After all, only 1.5% of the genome codes for proteins, while ~50% of the genome is high-copy repetitive elements, 3.5% of the genome is highly conserved sequences, and about 25% of the genome makes up genes and their regulatory elements. Since at least the 1970s, some scientists had claimed that the majority of the human genome was probably not functional since only protein coding sections of the genome (which is only 1-2% of the human genome) and very little non-protein coding was seen as useful. The remaining noncoding majority which was around 95% of the genome was seen as negligible or even without much use or 'junk'. However, this is no longer tenable in light of the updated research. The international collaboration called the ENCODE project actually tested most of the genome directly via biochemical methods and in 2012 discovered that at least 80% of the human genome was doing stuff and may not be genetic noise as was often assumed. It reported that the majority of our genome has biochemical functions due to this biochemical activity, which is a superior way to see what our cells are actually doing. The previous lower estimates, which came from comparative genomics approaches that did not rely on testing the genome directly, were a good start, but certainly not the last word. The the research was done by 440 scientists from 32 laboratories worldwide with more than 1,600 experiments. As of today the project has data from 3,300 experiments supporting the original results from ENCODE.

Compared the amounts of journal subscriptions one would have to have in order stay up to date with advances in cellular research, this text is a wise investment as it distills numerous advances and stable knowledge so far, in one book. The importance of this textbook as "the standard" was highlighted a short and affordable introduction that is often consulted by fellow researchers for its excellent images and detailed drawings of actual cellular processes, machinery and molecular crowding. It is called The Machinery of Life (seeing cells as nanotechnology). Another good text is Bionanotechnology: Lessons from Nature (cells remind me of a complex robot scientist named "Adam" that can develop biological experiments and interpret findings in its own and also lab-on-a-chip). Both are recommended for overviews of cellular machinery and processes.

For those interested in a system views of life from cells to society, please check out The Systems View of Life: A Unifying Vision. The discourse on the chain of prebiotic complexity (molecules to biomonomers to macromolecules to compartments to genetic code to metabolic networks to cells) and also the downward causation triggered by cellular signalling resulting in feedback looping to and from "genes to proteins to pathways to sub-cellular mechanisms to cells to tissues to organs to organism" are worth checking out. For those interested in the impact of cellular research on evolutionary theory - shifting towards a dynamic systems view of cells and life - one can check out Evolution: A View from the 21st Century and The Logic of Chance: The Nature and Origin of Biological Evolution.

Table of Contents for the 6th Edition:

INTRODUCTION TO THE CELL

1. Cells and Genomes
2. Cell Chemistry and Bioenergetics
3. Proteins

BASIC GENETIC MECHANISMS

4. DNA, Chromosomes, and Genomes
5. DNA Replication, Repair, and Recombination
6. How Cells Read the Genome: From DNA to Protein
7. Control of Gene Expression

WAYS OF WORKING WITH CELLS

8. Analyzing Cells, Molecules, and Systems
9. Visualizing Cells

INTERNAL ORGANIZATION OF THE CELL

10. Membrane Structure
11. Membrane Transport of Small Molecules and the Electrical Properties of Membranes
12. Intracellular Compartments and Protein Sorting
13. Intracellular Membrane Traffic
14. Energy Conversion: Mitochondria and Chloroplasts
15. Cell Signaling
16. The Cytoskeleton
17. The Cell Cycle
18. Cell Death

CELLS IN THEIR SOCIAL CONTEXT

19. Cell Junctions and the Extracellular Matrix
20. Cancer
21. Development of Multicellular Organisms
22. Stem Cells and Tissue Renewal
23. Pathogens and Infection
24. The Innate and Adaptive Immune Systems

0 of 0 people found the following review helpful.
OK textbook for Molecular Biology
By bheckel
I rented this textbook for a university-level Molecular Biology class that I taught. It is not my favorite textbook, but it is a reasonable book for more advanced molecular biology and cell studies. The text often transitions from one paragraph that is very surface-level in terms of content to a paragraph that contains complex content, so it is a little difficult to navigate if you are trying to be consistent in the depth of content you would like to cover or learn. The figures are decent, but not great. The writing is not too dry, but not particularly engaging.

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Sabtu, 13 November 2010

[W699.Ebook] Free PDF Warcraft Official Movie Novelization, by Christie Golden

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Warcraft Official Movie Novelization, by Christie Golden

The peaceful realm of Azeroth stands on the brink of war as its civilization faces a fearsome race of invaders: orc warriors fleeing their dying home to colonize another. As a portal opens to connect the two worlds, one army faces destruction and the other faces extinction. From opposing sides, two heroes are set on a collision course that will decide the fate of their family, their people and their home. So begins a spectacular saga of power and sacrifice in which war has many faces, and everyone fights for something.

  • Sales Rank: #249090 in Books
  • Published on: 2016-06-07
  • Released on: 2016-06-07
  • Original language: English
  • Number of items: 1
  • Dimensions: 6.90" h x .80" w x 4.20" l, .37 pounds
  • Binding: Mass Market Paperback
  • 304 pages
Features
  • Excusive Traycased Hardcover

Review
“Enthralling from the first page” - Gamers Sphere

“Exceptionally well written” - Nerdspan

“I like how well the story deals in moral ambiguity rather than sticking to the familiar script of orcs bad, humans good. There is honor, love, and valor on both sides, just as there is betrayal, corruption, and frailty.” -  VG Blogger

About the Author
Award-winning and seven-time New York Times bestselling author Christie Golden has written over forty novels and several short stories in the fields of science fiction, fantasy and horror. Among her many projects are over a dozen Star Trek novels, nearly a dozen for gaming giant Blizzard’s World of Warcraft and StarCraft novels, and three books in the nine-books Star Wars series, Fate of the Jedi,with Aaron Allston and Troy Denning.

Most helpful customer reviews

4 of 4 people found the following review helpful.
Nice book spoiler free review
By Anne
I played WOW once a few years ago, so I am not too familiar with its universe. I was curious enough to watch the movie, and I surprisingly enjoyed it. But I felt like I was missing a few things, and decided to read the novel to hopefully clear it up. This book was very well written in that it felt like I was watching the movie again with the scenes I felt were missing. It also answered questions I had and gave me a view into the character's heads. It made everything more gray instead of black and white "good vs bad guys." I enjoyed how it gave enough descriptions of everything without feeling like it needed a chapter to just paint a picture of the setting. And while I did like the fact that it didn't spend a large amount of time boring me with descriptions of the characters' travels, I was getting the impression that everything was taking place within a few miles of each other. Like the orc camp was just a few hours walk away from the capital and somehow everyone missed the massive orcs building stuff until a former prisoner guided them over. Other than that, I enjoyed reading this book!

1 of 1 people found the following review helpful.
A fun Middle Grade novelization of the WoW Movie
By Reasonable Reviewer
This follows the movie blow by blow with a few additions.

For example, we meet the main mage when he is going through the ceremony to become the Guardian.

You hear the thoughts and doubts of the protagonists, and you could not have picked up the same from the movie.

The book also is a bit more G-rated than the movie. For example, in the movie, Guldar drains the life of an elk to instill life in the baby orc. The book glosses over that.

1 of 1 people found the following review helpful.
Rewriting lore.
By Dainah
I don't know whether I just didn't read the reviews (or the description of the book) or what but when I got this today I realized it is a -novelization of the movie-. I loved the movie on its own merit, but I bristled (a lot) over the changes from the original stories written by Christie Golden. And now she's created a whole novel embracing those changes, essentially changing the lore she helped create in the first place. It's just disappointing. :(

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Senin, 08 November 2010

[F163.Ebook] PDF Download Admit You Hate Yourself (A Rev. MYN Book), by Mark Yoshimoto Nemcoff

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Admit You Hate Yourself (A Rev. MYN Book), by Mark Yoshimoto Nemcoff

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Admit You Hate Yourself (A Rev. MYN Book), by Mark Yoshimoto Nemcoff

The obstacles in your life do not prevent you from living your life. The obstacles in your life ARE your life.

Are you your own worst enemy? Do you find yourself constantly getting in the way of your own happiness? Then Admit You Hate Yourself is the reality check about your self-image that will arm you with the kind of mental tools you need to get from where you are in life to where you want to be.

Sometimes profane, but always profound, the Rev. MYN (a.k.a. best-selling and award-winning author Mark Yoshimoto Nemcoff) has coached people and large brands on ways to target and achieve their goals. As a new-media pioneer, he has been heavily involved in creating innovative web-based marketing for the better part of the last decade. Admit You Hate Yourself is the latest volume culled from his experiences in the trenches.

Mark Yoshimoto Nemcoff is a former Sirius Satellite Radio drive time show and TV host. As someone who has survived and thrived as a self-employed artist for nearly 20 years, he has the battle scars to prove the struggle to overcome life's roadblocks are well worth the fight.

  • Sales Rank: #171711 in Audible
  • Published on: 2012-06-13
  • Format: Unabridged
  • Original language: English
  • Running time: 139 minutes

Most helpful customer reviews

2 of 2 people found the following review helpful.
Way easier to understand than Rocky
By That Guy Ricky
As a grad Student with a 900 pg a week reading load, I rarely get a chance to read something that I want to read for the fun of it. I took advantage of the free download expecting to keep it in my kindle and read it little by little during my free time (mostly on the toilet). I started to read the book with the intention of only get through the first couple of pages and just couldn't put it down. End up doing the "All in one sitting" thing (not in the bathroom) and it was totally worth it. The book is jammed packed with a great Philosophy on life and the constant hustle that it takes to get to where you want to be. I feel like I read a two hour Rocky Speech, about not giving up and fighting for what you really want to do, and realizing that the journey is just as important as the destination... Well, with more enunciation. It doesn't come across like the regurgitated garbage that is usually in the typical self-help book. The Rev comes across as extremely relatable person and leaves you with a new found passion for your passion. Great read and I would recommend it to anyone. I would like to thank the author for the limited time free download, and I will be making sure I buy some his other books.

1 of 1 people found the following review helpful.
BEST.READ.EVER.
By Tessana Nemenski
Ok, the first time I read this, I was sitting in a hosptial, getting pumped up with antibotics and morphine.
It made sense. At least while I was on the morphine :)
No- all kidding aside, after i spent 4 days in the hosptial, I walked out in a rotten mood. Now, on top of everything else, I got a giant medical bill to pay. There goes all the money I was putting aside for my creative studio. In the midst of that, my business parter also came down with a medical issue that is going to take months to solve, so yeah. I was in a totally "why can't i ever catch a break" mood.
I went back and re-read the passages that I highlighted while I was in the hosptial. Something clicked. It was the proverbial "lightbulb" over my head like in a cartoon.
Yes- there have been a number of things that I felt like were holding me back. I couldn't do the traditional go to high school , graduate, go to college, graduate at 24 and go work in corporate America---- so on and so forth. My life is definatly not fitting in the peg hole of the "American tradition".
However, like Mark points out (and practically hits you over the head like---with a sledgehammer) its about the journey- not the destination. I realized, that despite EVERYTHING that has happened in my life, good bad otherwise, all of that has gotten me to the point that I am at now to be able to (try) to start my own company with people that are good at what they do and I can call my dear friends.
That's what got me out of the funk.
Sometimes we all need a swift kick in the butt and a wake up call.
Thanks for the call Mark!

1 of 1 people found the following review helpful.
Great ideas are ones that after having them you realize it should be common sense
By J. Duggins
Mark tells a series of personal stories of triumph and failure, mixed in with references to books, movies and a hero or two in order to make a few common sense, in retrospect, ideas clear. His starting premise is clear from the book title and in a sense can be equated with the old Freudian ideas of the Id and the Superego fighting for control. He encourages the reader to get out of his or her own way, aim for a better way (this better way is not suggested in the book but left up as an exercise for the reader.) and shoot for that goal.

His concepts are not ground breaking or alarming in any way but are presented in a fun, humorous and enjoyable manner. I found the time spent reading this book to be well spent.

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  • Sales Rank: #685070 in eBooks
  • Published on: 2016-02-19
  • Released on: 2016-02-19
  • Format: Kindle eBook

Most helpful customer reviews

2 of 2 people found the following review helpful.
Experience is everything!
By Jeff S.
You will read many how to guides by individuals who sound very elequent but don't have any experience. This book is great because it is written by someone who practices what they preach. Tim writes in a way that's easy to understand and that covers the main topics needed to succeed on the Turo platform.

1 of 1 people found the following review helpful.
I like to research before jumping into a venture
By Amazon Customer
Purchased this ebook, and found it contained very detailed steps on how to list a car using Turo to create a profitable side business. I like to research before jumping into a venture, and Tim has done a fantastic job mapping it out. For example, illustrating the Return on Investment or which IVR prompts to dial to reach Turo customer service. I love when the guess work is taken out. Highly recommend.

0 of 0 people found the following review helpful.
A True Understanding of TURO
By Sarah Gwen
Tim's book is super helpful in understanding the ins and outs of renting out your vehicle through TURO and his advice about developing a TURO business is indispensable. He's had a car totaled and was completely taken care of by TURO, giving me the reassurance I need to want to jump right in to renting vehicles through TURO. Thanks, Tim (and your wife too!) for doing the exploratory work for all of us and then sharing it here. True peer-to-peer business at its best!!
TURO can definitely boost your income and even become your main source if you follow Tim's well-laid out system!

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AIDS and Accusation: Haiti and the Geography of Blame (Comparative Studies of Health Systems and Medical Care), by Paul Farmer

Does the scientific "theory" that HIV came to North America from Haiti stem from underlying attitudes of racism and ethnocentrism in the United States rather than from hard evidence? Anthropologist-physician Paul Farmer answers in the affirmative with this, the first full-length ethnographic study of AIDS in a poor society.

  • Sales Rank: #2666079 in Books
  • Published on: 1992-08-26
  • Original language: English
  • Number of items: 1
  • Dimensions: 9.25" h x 6.25" w x .75" l,
  • Binding: Hardcover
  • 338 pages

From Library Journal
Physician and anthropologist Farmer studied the impact of AIDS on the impoverished people of Haiti, and his portrayal for his doctoral dissertation, of a small rural village--its clinic, religious life, folk healers, and voodoo beliefs--brings Haitian culture powerfully to life. He provides an extensive history of the country, finally exploring the connection between suffering and blame: Americans have blamed Haitians for "causing" AIDS, while Haitians have accused one another of "sending" it through sorcery. Rarely is a book based on a dissertation so engaging. Highly recommended for academic and subject collections.
- Judith Eannarino, Washington, D.C.
Copyright 1992 Reed Business Information, Inc.

Review
"Farmer's analysis . . . carefully postulates a trajectory of AIDS in the United States, Haiti, and the Caribbean, revealing the intimate economic and political links that allowed for the syndrome to appear simultaneously in the countries of the Western hemisphere. . . . Farmer renders a richly layered and nuanced ethnographic portrait." -- Guitele Nicoleau, Harvard Educational Review

"Farmer's sensitive exploration of the lives and deaths of the people at Do Kay give his study a distinctly human face and an emotional edge that moves the study and the reader beyond the cynical gaze of post-modernism and political economy. The book is at the same time fiercely personal and coldly objective. The result is both moving and illuminating." -- Randall M. Packard, Science

"[Farmer] explores Haitians' experiences and understanding of the disease with moving profiles of the first three AIDS sufferers in Do Kay, the village where he conducted field work from 1983 to 1990." -- Chronicle of Higher Education

From the Inside Flap
Praise for the first edition:

“Farmer’s sensitive exploration of the lives and deaths of the people at [the village of] Do Kay give his study a distinctly human face and an emotional edge.... The book is at the same time fiercely personal and coldly objective. The result is both moving and illuminating.”— Science

“Farmer renders a richly layered and nuanced ethnographic portrait.”— Harvard Educational Review

“This superbly crafted volume is dedicated to explaining and refuting a popular U.S. belief that AIDS came to the United States from Haiti. . . . Farmer has made an outstanding scholarly contribution to the ‘anthropology of suffering,’ the assessment of illness as perceived and experienced by a patient embedded in an interlocking fabric of culture and history.”— Medical Anthropology Quarterly

Most helpful customer reviews

0 of 0 people found the following review helpful.
Farmer is an amazing man. This book is packed with info
By Luna Xenia
Farmer is an amazing man. This book is packed with info, and it is a really great read, especially because many still have misconceptions about AIDS, America, and Haiti.

0 of 1 people found the following review helpful.
Aids ans Accusation exceeded my expectations with it's tracing of ...
By Dwight Underwood
Aids ans Accusation exceeded my expectations with it's tracing of aids in Haiti. It paints a picture that at times can be extremely hard to process.

0 of 1 people found the following review helpful.
highly recommended.
By Katie Rosenblatt
Really interesting book, highly recommended.

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